Eficacia del tratamiento con molsidomina más atenolol para el control de la hipertensión arterial

Authors

  • Haydeé Aurora del Pozo Jerez
  • Lizette Elena Leiva Suero
  • Aslín Gándara Reyes
  • Alina Pérez Pérez

Keywords:

Molsidomina, Atenolol, Hipertension arterial

Abstract

Introduction: The aim of present paper was to assess the antihypertensive effectiveness of Molsidomine, a vasodilator identified as direct donor of nitric oxide (NO) associated with low-doses of Atenolol compared to Atenolol as a monotherapy and also to identify the potential side effects.

Method: A double-blind controlled, clinical and randomized assay was carried out. Study sample included 50 patients assessed in the high blood pressure specialized consultation , which were distributed in two groups: Atenolol plus placebo (A group), and Atenolol plus Molsidomine (B Group) under a weekly control over four weeks increasing the dose according achieve tension control.

Results: Both therapeutical combinations showed its effectiveness to control the high blood pressure RR 0,95. Atenolol plus Molsidomine combination had an attributable improvement of 5% major. There were not significant adverse effects.

Conclusions: Molsidomine and Atenolol combination showed a greater antihypertensive effectiveness compared to Atenolol monotherapy, where the above mentioned improvement could be due to the nitric oxide (NO) effect on vascular endothelium suggesting that this drugs combination could to be of benefit for hypertensive patients presenting coexistent affections presenting a nitric oxide deficit. There were not significant side effects.

 

 

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Author Biographies

Haydeé Aurora del Pozo Jerez

Doctora en Ciencias Médicas. Especialista de II Grado en Medicina Interna Profesora Titular de Medicina Interna. Investigadora Titular.

Lizette Elena Leiva Suero

Doctora en Ciencias Médicas. Especialista de II Grado en Medicina Interna. Profesora Titular de Medicina Interna

Published

2009-02-15

How to Cite

1.
del Pozo Jerez HA, Leiva Suero LE, Gándara Reyes A, Pérez Pérez A. Eficacia del tratamiento con molsidomina más atenolol para el control de la hipertensión arterial . Acta Médica [Internet]. 2009 Feb. 15 [cited 2025 May 24];12(1). Available from: https://revactamedica.sld.cu/index.php/act/article/view/727

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