Combined therapy for noninvasive squamous carcinoma

Authors

  • Liz Burgois Leonard Hospital Docente Clínico Quirúrgico "Hermanos Ameijeiras".
  • Manuel Salazar Sedano Hospital Docente Clínico Quirúrgico "Hermanos Ameijeiras".
  • Rigoberto García Gómez Hospital Docente Clínico Quirúrgico "Hermanos Ameijeiras".
  • Carlos León Román Hospital Docente Clínico Quirúrgico "Hermanos Ameijeiras".

Keywords:

noninvasive squamous carcinoma, curettage, radiosurgery, cryosurgery, combined therapy

Abstract

Introduction: Squamous cell carcinoma located in the skin is a curable disease. There are several treatments to eradicate non-invasive squamous cell carcinomas (in situ), which can be used alone or in combination.
Objective: To evaluate the results of the combined therapy with curettage, radiosurgery and cryosurgery in the treatment of non-invasive squamous cell carcinoma.
Methods: A longitudinal and prospective descriptive study was carried out in 38 patients treated in the dermatology service of tumors of Hermanos Ameijeiras Clinical Surgical Hospital between January and December 2015.
Results: 47.4% were 70 years old or older. 55.3% were male. 76.3% referred photoexposure. 5.8% were actinic keratoses. The response to treatment was complete in 89.5%, 78.9% were satisfied with the procedure and only 21.1% had adverse effects.
Conclusions: In the combined therapy with curettage, cryosurgery and radiosurgery, a complete response and a good degree of satisfaction was achieved in the majority of the patients studied, as well as a low frequency of adverse effects, among which alopecia was highlighted.

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Author Biographies

Liz Burgois Leonard, Hospital Docente Clínico Quirúrgico "Hermanos Ameijeiras".

Servicio Dermatología

Carlos León Román , Hospital Docente Clínico Quirúrgico "Hermanos Ameijeiras".

Lic. Enfermería. Doctor en Ciencias de la Salud. Profesor titula.

References

Weedon D. Piel Patología. Madrid: Marbán Libros; 2012.

Vajdic CM, Kricker A, Giblin M, McKenzie J, Aitken JF, Giles GG, et al. Artificial ultravioletradiation and ocular melanoma in Australia. Int J Cáncetr. 2014;112:896-900.

Karia PS, Han J, Schmults CD. Cutaneous squamous cell carcinoma: estimated incidence of disease, nodal metastasis, and deaths from disease in the United States, 2012. J Am Acad Dermatol. 2013;68(6):957-66.

Xiang F, Lucas R, Hales S, Neale R. Incidence of nonmelanoma skin cancer in relation to ambient UV radiation in white populations, 1978-2012: empirical relationships. JAMA Dermatol. 2014;150(10):1063-71.

Garavis J. Precáncer y cáncer cutáneo II. Semergen. 2003;29:532-41.

National Comprehensive Cancer Network (NCCN). Clinical practice guide lines in oncology. Basal cell and squamous cell skin cancers I. 2012 [citado 10 Dic 2014]. Disponible en: www.nccn.org/professionals/physician_gls/f_guidelines.asp

Karagas MR, Nelson HH, Sehr P, Waterboer T, Stukel TA, Andrew A, et al. Human papilloma virus infection and incidence of squamouscell and basal cell carcinomas of theskin. J NatlCancer Inst. 2006;98:389-95.

Frost CA, Green AC. Epidemiology of solar keratoses. Br J Dermatol. 1994;131:455-64.

Marks R, Jolley D, Lectsas S, Foley P. The role of childhood exposure to sunlight in the development of solar keratoses and non-melanocytic skin cancer. Med J Aust. 1990;152:62-6.

Green A, Beardmore G, Hart V, Leslie D, Marks R, Staines D. Skincancer in a Queensland population. J Am AcadDermatol. 1988;19:1045-52.

Memon AA, Tomenson JA, Bothwell J, Friedmann PS. Prevalence of solar damage and actinickeratosisin a Merseysidepopulation. Br J Dermatol. 2000;142:1154-9.

Tórtora ME. Aspectos epidemiológicos del carcinoma escamoso [tesis]. Argentina: Universidad Nacional de La Plata; 2015.

Giraldo Sierra C, Montes Gallo C, Zuleta Tobón JJ, Correa LA, Vasco CM, Sanclemente Mesa G. Caracterización clínica, epidemiológica e histopatológica de pacientes con diagnóstico de queratosis actínica. Iatreia. 2012;25:20-30.

Buendía Eisman A, Muñoz Negro JE, Serrano Ortega S. Epidemiología del cáncer cutáneo no melanoma. Piel. 2002;17(1):3-6.

Holman CD, Armstrong BK, Evans PR, Lumsden GJ, Dallimore KJ, Meehan CJ, et al. Relationship of solar keratosis and history of skincancer to objective measures of actinicskindamage. Br J Dermatol. 1984;110:129-38.

Benvenuto Andrade C, Zen B, Fonseca G, De Villa D, Cestari T. Sunexposure and sun protection habits among high-schooladolescents in Porto Alegre, Brazil. Photochem Photobiol. 2005;81:630-5.

Kempf W, Mertz KD, Hofbauer GF, Tinguely M. Skincancer in organtransplant recipients. Pathobiology. 2013;80:302-9.

Boccardo E, Lepique AP, Villa LL. The role of inflammation in HPV carcinogenesis. Carcinogenesis. 2010;31:1901-12.

Alfonso JH, Martinsen JI, Pukkala E, Weiderpass E, Tryggvadottir L, Nordby KC, et al. Occupation and relative risk of cutaneous squamous cell carcinoma (cSCC): A 45-year follow-up study in 4 Nordic countries. J Am Acad Dermatol. 2016;75:548-55.

Sánchez Conejo-Mir J. Carcinomas epiteliales. Dermatología oncológica. En: Guillén C, editor. Oncología y hematología. Madrid: Nova Sidonia; 2012. p. 7-18.

Schmults CD, Karia PS, Carter JB, Han J, Qureshi AA. Factors predictive of recurrence and death from cutaneous squamous cell carcinoma: a 10-year, single-institution cohort study. JAMA Dermatol. 2013;149:541-7.

Kalita C, Kalita LK, Baruah UD, Sarma UD. A clinic- epidemiological study of cutaneous malignancy-a hospital based study at Gauhati Medical College& Hospital, Guwahati, Assam. J Evid Based Med Healthc. 2016 [citado 20 Jun 2016];3:1863-9. Disponible en: http://www.jebmh.com/data_pdf/Lohith %20Kalita %20- %201- %20FINAL.pdf

Breuninger H, Eigentler T, Bootz F, Hauschild A, Kortmann RD, Wolff K, et al. Brief S2K guidelines cutaneous squamous cell carcinoma. J Dtsch Dermatol Ges. 2013;11(Suppl 3):37-45.

Basal cell and squamous cell skincancers. NCCN clinical practice guidelines in oncology (NCCN Guidelines) Version I 2013 [citado 20 Jun 2016]. Disponible en: www.nccn.org/professionals/physician_gls/f_guidelines.asp

Wolfe J. Non melanoma skincancers: basal cell and squamous cell carcinoma. In: Abeloff: Clinical oncology. 5th ed. Philadelphia: Churchill Living stone Inc; 2015. p. 1351-4.

Habif TP. Premalignant and malignant non melanoma skin tumors. En: Habif TP, editor. Clinical dermatology. 6th ed. St Louis: Mosby Inc; 2014. p. 860-72.

MacFarlane DF, El Tal AK. Cryo immune therapy: superficial basal cell cancer and squamous cell carcinoma in situ treated with liquid nitrogen followed by imiquimod. Arch Dermatol. 2011;147:1326-27.

Lee CN, Pan SC, Lee JYY, Wong TW. Successful treatment of cutaneous squamous cell carcinoma within tralesional cryo surgery. Medicine. 2016;95:e4991.

Published

2017-11-28

How to Cite

1.
Burgois Leonard L, Salazar Sedano M, García Gómez R, León Román C. Combined therapy for noninvasive squamous carcinoma. Acta Médica [Internet]. 2017 Nov. 28 [cited 2025 Apr. 30];18(2). Available from: https://revactamedica.sld.cu/index.php/act/article/view/776

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Artículos originales