Factors associated with remission in rheumatoid arthritis.
Keywords:
remisión sostenida; factores asociados; artritis reumatoideAbstract
Introduction: Rheumatoid arthritis (RA) is a multisystem chronic inflammatory disease of unknown etiology and autoimmune nature that affects peripheral joints symmetrically. Objective: identify the factors that are associated with sustained remission in patients with RA. Method: A retrospective, analytical-observational cohort study was carried out with patients who belong to the protocolized Rheumatoid Arthritis consultation. Results: the female gender predominated by 89%, white skin color 68% and a mean age of 53.11± 13.1. An association was found between sustained remission of RA and the absence of large joint involvement. The clinical laboratory variables that were associated with remission or not of RA were CRP and rheumatoid factor. Conclusions: In the present study, the demographic variables analyzed, age, sex, and skin color, were not prognostic factors of sustained remission. The clinical and laboratory variables that are associated with the state of sustained remission in patients with RA were not taking large joints, and low levels of CRP and RF. Imaging variables, within the scope of the present study, were not useful as a prognostic factor to predict sustained remission of patients.
Downloads
References
1. Díaz-González F, Hernández-Hernández MV. Rheumatoid arthritis. Med Clin (Barc). 2023 Dec 22;161(12):533-42. English, Spanish. doi: 10.1016/j.medcli.2023.07.014. Epub 2023 Aug 9. PMID: 37567824.
2. Medina-Velásquez Yimy F, Narváez María Isabel, Atuesta Javier, Díaz Eybar, Motta Orfa, Quintana López Gerardo et al . Variación en la definición del examen articular para la clinimetría de la artritis reumatoide: resultados de una encuesta realizada a un grupo de reumatólogos colombianos. Rev.Colomb.Reumatol. [Internet]. 2020 Sep [cited 2024 Dec 18] ; 27( 3 ): 149-154. Available from: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0121-81232020000300149&lng=en. Epub Apr 23, 2021. https://doi.org/10.1016/j.rcreu.2020.02.003.
3. Yang Y, Hong Q, Zhang X, Liu Z. Rheumatoid arthritis and the intestinal microbiome: probiotics as a potential therapy. Front Immunol. 2024 Mar 6;15:1331486. doi: 10.3389/fimmu.2024.1331486. PMID: 38510244; PMCID: PMC10950920.
4. O'Neil LJ, Alpízar-Rodríguez D, Deane KD. Rheumatoid Arthritis: The Continuum of Disease and Strategies for Prediction, Early Intervention, and Prevention. J Rheumatol. 2024 Apr 1;51(4):337-49. doi: 10.3899/jrheum.2023-0334. PMID: 38224993; PMCID: PMC10984790.
5. da Mota LM, Brenol CV, Palominos P, Pinheiro Gda R. Rheumatoid arthritis in Latin America: the importance of an early diagnosis. Clin Rheumatol. 2015 Mar;34 Suppl 1(Suppl 1):S29-44. doi: 10.1007/s10067-015-3015-x. Epub 2015 Jul 25. PMID: 26208442; PMCID: PMC4617839.
6. Miguel-Lavariega D, Elizararrás-Rivas J, Villarreal-Ríos E, Baltiérrez-Hoyos R, Velasco-Tobón U, Vargas-Daza ER, Galicia-Rodríguez L. Perfil epidemiológico de la artritis reumatoide [Epidemiological profile of rheumatoid arthritis]. Rev Med Inst Mex Seguro Soc. 2023 Sep 4;61(5):574-582. Spanish. doi: 10.5281/zenodo.8316427. PMID: 37757464; PMCID: PMC10599789.
7. Chico Capote A, Bertoli González L, Estévez del Toro MH, Kokuina E, Casas Figueredo N, Sánchez Bruzón Y. Manifestaciones extrarticulares y anticuerpos contra péptidos cíclicos citrulinados en artritis reumatoide. Rev Cubana Med [Internet]. 14 de diciembre de 2021 [citado 18 de diciembre de 2024];60(4). Disponible en: https://revmedicina.sld.cu/index.php/med/article/view/2520
8. Ruiz-Cruz M, Hübbe-Tena C, Prado-Larrea C, Cheja-Kalb, Rashel, Concha-del-Río, Luz Elena. Escleritis y anticuerpos antipéptido cíclico citrulinado como presentación inicial de artritis reumatoide. An Med Asoc Med Hosp ABC. 2020;65(4):262-69. doi:10.35366/97463.
9. Katchamart W, Johnson S, Lin HJ, Phumethum V, Salliot C, Bombardier C. Predictors for remission in rheumatoid arthritis patients: A systematic review. Arthritis Care Res (Hoboken). 2010 Aug;62(8):1128-43. doi: 10.1002/acr.20188. PMID: 20235210.
10. Mai A, Krause D, Klaassen-Mielke R, Meiszl K, Timmesfeld N, Baraliakos X, et al. Comparing outcomes of patients with early active rheumatoid arthritis initially treated on an inpatient or outpatient basis: a posthoc analysis of the CORRA trial. RMD Open. 2024 Oct 22;10(4):e004430. doi: 10.1136/rmdopen-2024-004430. PMID: 39438083; PMCID: PMC11499839.
11. Niu Q, Hao J, Li Z, Zhang H. Helper T cells: A potential target for sex hormones to ameliorate rheumatoid arthritis? (Review). Mol Med Rep. 2024 Dec;30(6):215. doi: 10.3892/mmr.2024.13339. Epub 2024 Sep 27. PMID: 39370806; PMCID: PMC11450432.
12. Yildirim K, Karatay S, Melikoglu MA, Gureser G, Ugur M, Senel K. Associations between acute phase reactant levels and disease activity score (DAS28) in patients with rheumatoid arthritis. Ann Clin Lab Sci 2004;34(4):423-6.
13. Warjukar PR, Mohabey AV, Jain PB, Bandre GR. Decoding the Correlation Between Inflammatory Response Marker Interleukin-6 (IL-6) and C-reactive Protein (CRP) With Disease Activity in Rheumatoid Arthritis. Cureus. 2024 Jun 23;16(6):e62954. doi: 10.7759/cureus.62954. PMID: 39050325; PMCID: PMC11265957.
14. Li Y, Yu H, Feng J. Role of chemokine-like factor 1 as an inflammatory marker in diseases. Front Immunol. 2023 Feb 14;14:1085154. doi: 10.3389/fimmu.2023.1085154. PMID: 36865551; PMCID: PMC9971601.
15. Braig D, Nero TL, Koch HG, Kaiser B, Wang X, Thiele JR, et al. Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites. Nat Commun 2017 Jan 23;8:14188.
16. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988 Mar;31(3):315-24. doi: 10.1002/art.1780310302. PMID: 3358796.
17. Wu CY, Yang HY, Luo SF, Lai JH. From Rheumatoid Factor to Anti-Citrullinated Protein Antibodies and Anti-Carbamylated Protein Antibodies for Diagnosis and Prognosis Prediction in Patients with Rheumatoid Arthritis. Int J Mol Sci. 2021 Jan 12;22(2):686. doi: 10.3390/ijms22020686. PMID: 33445768; PMCID: PMC7828258.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Araceli Chico Capote, Miguel Hernán Estévez del Toro, Claudia Serpa Videaux, Rolando Dayan Puente Carmona
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Aquellos autores/as que tengan publicaciones con esta revista, aceptan los términos siguientes:
- Los autores/as conservarán sus derechos de autor y garantizarán a la revista el derecho de primera publicación de su obra, el cuál estará simultáneamente sujeto a la Licencia de reconocimiento de Creative Commons que permite a terceros compartir la obra siempre que se indique su autor y su primera publicación esta revista.
- Los autores/as podrán adoptar otros acuerdos de licencia no exclusiva de distribución de la versión de la obra publicada (p. ej.: depositarla en un archivo telemático institucional o publicarla en un volumen monográfico) siempre que se indique la publicación inicial en esta revista.
- Se permite y recomienda a los autores/as difundir su obra a través de Internet (p. ej.: en archivos telemáticos institucionales o en su página web) antes y durante el proceso de envío, lo cual puede producir intercambios interesantes y aumentar las citas de la obra publicada. (Véase El efecto del acceso abierto).
