Idiopathic granulomatous mastitis: an inflammatory breast cancer simulator, a great diagnostic and therapeutic challenge.
Keywords:
Palabras clave: mastitis granulomatosa idiopática, absceso de mama, cáncer inflamatorio de mama, terapia esteroidea.Abstract
Introduction: Granulomatous mastitis is a benign breast disease characterized by the formation of granulomas in the lobules. It occurs in women of reproductive age, commonly with a history of breastfeeding. It manifests as the formation of abscesses or tumors. Diagnosis requires a biopsy and the exclusion of certain infectious processes and autoimmune diseases. Treatment is controversial; antimicrobials, steroids, immunosuppressants, biologic therapy, and surgery have been used.Objective: To describe the case of a patient diagnosed with erythema nodosum and enlargement in the left breast.Case presentation: A 24-year-old female patient was admitted to the Internal Medicine Department with a diagnosis of erythema nodosum associated with a tumor, pain, redness, and discharge from a lesion in the left breast. She had previously undergone surgery to drain an abscess. A biopsy was taken from the tumor area in the operating room, revealing a diagnosis of idiopathic granulomatous mastitis. She was treated with steroid therapy until resolution.
Conclusions: Idiopathic granulomatous mastitis is a rare condition that affects women of childbearing age and is difficult to diagnose due to the complexity of its clinical presentation. It can be confused with malignant breast lesions such as inflammatory carcinoma. Diagnosis requires optimal multidisciplinary work and close follow-up of patients with the condition. It is a disease that not only affects the aesthetics of our patients but also causes psychological disorders in young, sexually active women, who associate these symptoms with the tragedy of cancer.
Keywords: idiopathic granulomatous mastitis, breast abscess, inflammatory breast cancer, steroid therapy.
Downloads
References
1. Cadena R, Tapia E, Yametti C, Salazar R. Adalimumab in a patient with refractory idiopathic granulomatous mastitis: a case report. Breast J. 2020; 27:99–102. https://doi.org/10.1111/tbj.14050.
2. Fernández C, Ruiz A, Laguna M, Diaz B, Marin S, Hernández J. Mastitis granulomatosa. Caso clínico y revisión de la literatura. Rev Chil Obstet Ginecol. 2021;86(2):247–54. https://doi.org/10.4067/s0717-75,262,021,000,200,247.
3. Omranipour R, Vasigh M. Mastitis, breast abscess, and granulomatous mastitis. Adv Exp Med Biol. 2020; 1252: 53-61. https://doi.org/10.1007/978-3-030-41596-97.
4. Benlghazi A, Messaoudi H, Belouad M, Bouhou R, Elhassani M. Idiopathic granulomatous mastitis: a challenging case report and comprehensive review of the literature. Int J Surg Case Rep. 2024;118, 109555. https://doi.org/10.1016/j.ijscr.2024.109555.
5. R.R. Pimentel León, R.M. Núñez Rodríguez, y M.D.S. Rebollar Vega. Musleh A, Shrateh O, Ishtaya N, Abbadi K, Asbah M, Ayyad S. A. single center experience with a rare clinical entity of idiopathic granulomatous mastitis: case series and review of the literature. Int J Surg Case Rep. 2024;115, 109232. https://doi.org/10.1016/j.ijscr.2024.109232.
6. Elahi A, Eyvazi A, Faegh A, Mehrpoor G. Rheumatologic manifestations of female patients with idiopathic granulomatous mastitis. Egypt Rheumatol. 2024; 46:86–9. https://doi.org/10.1016/j.ejr.2024.02.002.
7. Zhang Q, Zhang W, Zhao Y. The effect of local steroid administration on idiopathic granulomatous mastitis: a systematic review and meta-analysis. J Surg Res. 2024; 295:511–21. https://doi.org/10.1016/j.jss.2023.11.024.
8. Durán M, Salinero M, Sanchez A, Freijanes P, Romero S, Oses J. Avances en el tratamiento de la mastitis granulomatosa. diopática: utilidad de micofenolato de mofetilo. Rev Senol Patol Mamaria. 2022; 35:10–5. https://doi.org/10.1016/j.senol.2021.03.003.
9. Postolova A, Troxell ML, Wapnir IL, Genovese MC. Methotrexate in the treatment of idiopathic granulomatous mastitis. J Rheumatol. 2020; 6:924–7. https://doi.org/10.3899/jrheum.181205.
10. Konan A, Kalyoncu U, Dogan I, Kiliç YA, Karakoç D, Akdogan A, et al. Combined long-term steroid and immunosuppressive treatment regimen in granulomatous mastitis. Breast Care (Basel). 2012;7(4):297–301. https://doi.org/10.1159/000341388.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Marlen Bárbara Negrín Suárez, Jorge Lázaro Loys Fernández , Ariel Rodríguez García

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Aquellos autores/as que tengan publicaciones con esta revista, aceptan los términos siguientes:
- Los autores/as conservarán sus derechos de autor y garantizarán a la revista el derecho de primera publicación de su obra, el cuál estará simultáneamente sujeto a la Licencia de reconocimiento de Creative Commons que permite a terceros compartir la obra siempre que se indique su autor y su primera publicación esta revista.
- Los autores/as podrán adoptar otros acuerdos de licencia no exclusiva de distribución de la versión de la obra publicada (p. ej.: depositarla en un archivo telemático institucional o publicarla en un volumen monográfico) siempre que se indique la publicación inicial en esta revista.
- Se permite y recomienda a los autores/as difundir su obra a través de Internet (p. ej.: en archivos telemáticos institucionales o en su página web) antes y durante el proceso de envío, lo cual puede producir intercambios interesantes y aumentar las citas de la obra publicada. (Véase El efecto del acceso abierto).