Case report of head and neck cutaneous angiosarcoma with nasal lesion and histopathological analysis

Authors

Keywords:

cutaneous angiosarcoma, head, neck

Abstract

Cutaneous angiosarcoma is a rare malignant malformation of vascular origin, with very aggressive behavior and poor prognosis, affecting mainly elderly men. Clinically, it shows as a rapidly growing erythematous-violaceous plaque or nodule, which usually ulcerates and becomes superinfected. Its treatment is not clearly defined; wide local resection and subsequent adjuvant radiotherapy is considered one of the best options to reduce the risk of relapse and improve survival.

Presenting the case of an 85-year-old male patient with an erythematous-violaceous lesion located in the right nasal ala. Due to the initial clinical characteristics of the lesion, rhinophyma was considered as a diagnostic possibility. However, given the asymmetry, violaceous coloration and rapid growth, it was decided to perform a histological and immunohistochemical study, obtaining a report of cutaneous angiosarcoma.

Downloads

Download data is not yet available.

References

Holloway CL, Turner AR, Dundas GS. Cutaneous angiosarcoma of the scalp: a case report of sustained complete response following liposomal Doxorubicin and radiation therapy. Sarcoma. 2005;9(1-2):29-31. DOI: https://doi.org/10.1080/13577140500043948

Hodgkinson DJ, Soule EH, Woods JE. Cutaneous angiosarcoma of the head and neck. Cancer. 1979;44(3):1106-13. DOI: https://doi.org/10.1002/1097-0142(197909)44:3<1106::aid-cncr2820440345>3.0.co;2-c

Terada T. Fatal poorly differentiated angiosarcoma of the scalp. International journal of clinical and experimental pathology. Int J Clin Exp Pathol. 2010 [acceso 29/09/2021];3(5):541-4. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897108/

Goette DK, Detlefs RL. Postirradiation angiosarcoma. J Am Acad Dermatol. 1985;12:922-6. DOI: https://doi.org/10.1016/S0190-9622(85)70114-4

Stewart FW, Treves N. Lymphangiosarcoma in postmastectomy lymphedema. Cancer. 1948;1:64-81. DOI: https://doi.org/10.1002/1097-0142(194805)1:1<64::AID-CNCR2820010105>3.0.CO;2-W

Rajinikanth J, Gaikwad P, Raj JP, Tirkey AJ, Muthusami JC. Angiosarcoma of the scalp. Otolaryngol Head Neck Surg. 2008;138:255-6. DOI: https://doi.org/10.1016/j.otohns.2007.11.007

Maddox JC, Evans HL. Angiosarcoma of skin and soft tissue: a study of forty-four cases. Cancer. 1981;48(8):1907-21. DOI: https://doi.org/10.1002/1097-0142(19811015)48:8<1907::aid-cncr2820480832>3.0.co;2-t

Sánchez RA, Jaramillo LF, Ramírez J. Angiosarcoma cutáneo en la región nasal tratado con radioterapia: reporte de caso. Universitas Medica. 2018;59(3):1-5. DOI: https://doi.org/10.11144/Javeriana.umed59-3.acrn

Behjati S, Tarpey PS, Sheldon H, Martincorena I, Van Loo P, Gundem, et al. Recurrent PTPRB and PLCG1 mutations in angiosarcoma. Nature genetics. 2014;46(4):376-9. DOI: https://doi.org/10.1038/ng.2921

Shin JY, Roh SG, Lee NH, Yang KM. Predisposing factors for poor prognosis of angiosarcoma of the scalp and face: Systematic review and meta-analysis. Head & neck. 2017;39(2):380-6. DOI: https://doi.org/10.1002/hed.24554

Holden CA, Spittle MF, Jones EW. Angiosarcoma of the face and scalp, prognosis and treatment. Cancer. 1987;59(5):1046-57. DOI: https://doi.org/10.1002/1097-0142(19870301)59:5<1046::aid-cncr2820590533>3.0.co;2-6

Obeng MK, Hernandez A, Dastgir A, Adegboyega PA, Salinas P, Gore DC. Angiosarcoma of the scalp with calvarium involvement in a 50-year-old AfricanAmerican man. J Nat Med Assoc. 2004 [acceso 15/03/2005];96(11):1507-12. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2568600/

Lara, H, Weinberg M, Baratam P, Horn J, Ward K, Styler, M. Angiosarcoma of the face: A case study and literature review of local and metastatic Angiosarcoma. Case Rep Oncol. Med. 2021:8823585. DOI: https://doi.org/10.1155/2021/8823585

Rosai and Ackerman’s Surgical Pathology. 10th ed. Missouri: Elsevier; 2012. p. 1863-4. 41.

Miettinen M, Wang ZF, Paetau A, Tan SH, Dobi A, Srivastava S. ERG transcription factor as an immunohistochemical marker for vascular EMA/Glut1- positive perineural cells and CD 34 -positive fibroblastic cells in peripheral nerve sheath tumors. Mod. Pathol. 2003;16(4):293-8. DOI: https://doi.org/10.1097/PAS.0b013e318206b67b

DeYoung BR, Swanson PE, Argenyi ZB, Ritter JH, Fitzgibbon JF, Stahl DJ, et al. CD31 immunoreactivity in mesenchymal neoplasms of the skin and subcutis: report of 145 cases and review of putative immunohistologic markers of endothelial differentiation. Journal of cutaneous pathology. 1995;22(3):215-22. DOI: https://doi.org/10.1111/j.1600-0560.1995.tb00741.x

Rao P, Lahat G, Arnold C, Gavino AC, Lahat S, Hornick JL, et al. Angiosarcoma: a tissue microarray study with diagnostic implications. The American Journal of dermatopathology. 2013;35(4):432-7. DOI: https://doi.org/10.1097/DAD.0b013e318271295a

Patel VB, Speer TW. Successful treatment of an angiosarcoma of the nose with radiation therapy. Case reports in oncology. 2012;5(3):570-5. DOI: https://doi.org/10.1159/000343675

Ishida Y, Otsuka A, Kabashima K. Cutaneous angiosarcoma: update on biology and latest treatment. Current opinion in oncology. 2018;30(2):107-12. DOI: https://doi.org/10.1097/CCO.0000000000000427

Published

2023-12-20

How to Cite

1.
Iturre Rodríguez CD, Moore Zielley T, Salazar Sedano M, Arteaga Hernández E. Case report of head and neck cutaneous angiosarcoma with nasal lesion and histopathological analysis. Acta Médica [Internet]. 2023 Dec. 20 [cited 2025 Mar. 13];24(3). Available from: https://revactamedica.sld.cu/index.php/act/article/view/268

Issue

Section

Presentación de caso